منابع مشابه
HDL and cardiovascular-disease risk--time for a new approach?
Clinical and epidemiologic studies have consistently shown that low levels of high-density lipoprotein (HDL) cholesterol are strongly associated with an increase in the risk of coronary artery disease.1 Moreover, hypercholesterolemic mice with genetic defects in HDL metabolism are markedly atherosclerotic,2,3 providing compelling evidence that HDL is a key modulator of the disease in animal mod...
متن کاملNon-HDL Cholesterol and Evaluation of Cardiovascular Disease Risk
Cardiovascular disease (CVD), such as coronary heart disease (CHD), is the most frequent cause of death worldwide, especially in developed countries. The latest recommendations of European and American Cardiological Associations emphasize the role of non-HDL cholesterol (non-HDL-C) in evaluating the risk of CVD. Although this parameter has a lot of advantages, it is rarely used by general pract...
متن کاملHDL cholesterol, apolipoproteins, and cardiovascular risk in hemodialysis patients.
High concentrations of HDL cholesterol are considered to indicate efficient reverse cholesterol transport and to protect from atherosclerosis. However, HDL has been suggested to be dysfunctional in ESRD. Hence, our main objective was to investigate the effect of HDL cholesterol on outcomes in maintenance hemodialysis patients with diabetes. Moreover, we investigated the associations between the...
متن کاملHDL and cardiovascular risk: is cholesterol in particle subclasses relevant?
Dyslipidaemia is one of the major risk factors for the development of cardiovascular disease, which remains the leading cause of death in the world. Despite major advances in the treatment of dyslipidaemia, residual cardiovascular risk remains high in a significant number of patients, a fact that has prompted intensive investigation of medications raising HDL-cholesterol (HDL-C). Indeed, robust...
متن کاملHDL-cholesterol levels and cardiovascular risk: acCETPing the context.
High levels of plasma high-density lipoprotein cholesterol (HDL-C) are associated with a decreased risk of cardiovascular disease. Cholesterol ester transfer protein (CETP) facilitates the transfer or cholesteryl esters from HDL to triglyceride-rich lipoproteins, and its inhibition raises HDL-C levels. Accordingly, interest has focused on CETP inhibition to augment current lipid-lowering strate...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.280958